MCL

Medicinal Chemistry Lab (MCL)

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Faculty
David Julián Sanabria-Ríos, Ph.D.

Contact information

Faculty of Science and Technology -Department of Natural Sciences 4th Floor -John Will Harris Building
Inter American University of Puerto Rico - Metropolitan Campus PO Box 191293 San Juan, PR 00919

Email: dsanabria@intermetro.edu
Office: 450
Labs : 403 and 435-B
Office Phone: (787) 250-1912, Ext. 2465
Lab phone: (787) 250-1912, Ext 2313 and 2332

Rank/Discipline
Associate Professor and Researcher/ Organic Chemist, Medicinal Chemist, Natural Product Researcher, and Chemical Education Researcher (CER)

Courses that i teach
Organic Chemistry I (CHEM 2221) and Organic Chemistry II (CHEM 2222)

Education & Specialty Certification
Post Doctorate Experience, 2009, Miami University, Oxford, Ohio PhD, 2007, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico

 
Publications
  • Giménez-Moreira,, L.; Orellano, E. A.; Rosado, K.; Guido, R. V. C.; Andricopulo, A. D.; Ortiz-Soto, G.; Rodríguez, J. W.; Sanabria-Ríos, D. J.; Carballeira, N. M. The (5Z)-5-pentacosenoic and 5-pentacosynoic acids Inhibit the HIV-1 reverse transcriptase. Lipids 2015, 50 (10), 1043-1050.

  • Getino,, M.; Sanabria-Ríos, D.J; Fernández-López, R.; Campos, J.; Martinez, M.; Fernández, A.; Carballeira; N. M.; de la Cruz; F. Synthetic fatty acids prevent plasmid-mediated horizontal gene transfer. mBio 2015, 6(5), e01032-15, DOI: 10.1128/mBio.01032-15

  • Sanabria-Rios, D. J.; Rivera-Torres, Y.; Rosario, J.; Rios, C.; Gutierrez, R.; Carballeira, N. M.; Velez, C.; Zayas, B.; Alvarez-Colon, F.; Ortiz-Soto, G.; Serrano, V.; Altieri-Rivera, J.; Rios-Olivares, E.; Rodriguez, J. W. Synthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activity. Bioorg. Med. Chem. Lett. 2015, 25, 2174-2180, DOI: 10.1016/j.bmcl.2015.03.065

  • . Sanabria-Rios, D. J.; Rivera-Torres, Y.; Maldonado-Dominguez, G.; Dominguez, I.; Rios, C.; Diaz, D.; Rodriguez, J. W.; Altieri-Rivera, J. S.; Rios-Olivares, E.; Cintron, G.; Montano, N.; Carballeira, N. M. Antibacterial activity of 2-alkynoic fatty acids against multidrug-resistant bacteria. Chem. Phys. Lipids 2014, 178, 84-91, DOI: 10.1016/j.chemphyslip.2013.12.006

  • Carballeira, N. M.; Cartagena, M.; Sanabria, D.j.; Tasdemir, D.; Prada, C. F.; Reguera, R. M.; Balana-Fouce, R. 2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani. Bioorg. Med. Chem. Lett. 2012, 22, 6185-6189. DOI: 10.1016/j.bmcl.2012.08.019.

  • Tasdemir, D.; Sanabria, D.; Lauinger, A.; Tarun, A.; Herman, R.; Perozzo, R.; Zloh, M.; Kappe, S. H.; Brun, R.; Carballeira, N. M. 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorganic & Medicinal Chemistry 2010, 18 (21), 7475-7485, DOI: 10.1016/j.bmc.2010.08.055

  • Sanabria-Ríos, D.; Bretz, S. L. Investigating the relationship between faculty cognitive expectations about learning chemistry and the construction of exam questions. Chemistry Education Research and Practice 2010,11, 212-217, DOI: 10.1039/C005470B

  • . Sanabria-Ríos, D.; Montes, I. Assessment of organic inquiry-based laboratory experiences targeting different learning styles: ethnographic study. The Chemical Educator 2010, 14, 1-11, DOI: 10.1007/s00897102234a

  • Carballeira, N. M.; Sanabria, D.; Oyola, D. An improved synthesis for the (Z)-14-methyl-9-pentadecenoic acid and its topoisomerase I inhibitory activity. Arkivoc 2007, 8, 49-57 (See article)

  • Carballeira, N. M.; Sanabria, D.; Cruz, C.; Parang, K. The 2,6-Hexadecadiynoic acid and the 2,6-nonadecadiynoic acid: Novel synthetic acetylenic fatty acids with strong antifungal activity. Lipids 2006, 41, 507-511, DOI: 10.1007/s11745-006-5124-4.

  • Montes, I.; Sanabria, D.; García, M.; Castro, J.; Fajardo, J. A Greener Approach to Aspirin Synthesis Using Microwave Irradiation. Journal of Chemical Education 2006, 83, 628-631, DOI: 10.1021/ed083p628

  • Carballeira, N. M.; Sanabria, D.; Parang, K. Total synthesis and further scrutiny of the in vitro antifungal activity of 6-nonadecynoic acid. Archiv der Pharmazie: Chemistry in Life Sciences 2005, 338, 441-443, DOI: 10.1002/ardp.200500102

  • Carballeira, N. M.; Sanabria, D.; Ayala, N. L.; Cruz, C. A stereoselective synthesis for the (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid and its monounsaturated analog (Z)-14-methyl-9-pentadecenoic acid. Tetrahedron Letters 2004, 45, 3761-3763, DOI: 10.1016/j.tetlet.2004.03.078

  • Montes, I.; Lai, C.; Sanabria, D. Like dissolves like: A classroom demonstration and a guided-inquiry experiment for organic chemistry. Journal of Chemical Education 2003, 80, 447-449, DOI: 10.1021/ed080p447

 

 

 

 
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